I noticed something odd yesterday when running a synth through the RFX 24-bit card...
When I have an External Input enabled in Multimode (the alternative to "binding" the inputs), certain types of activity in my DAW (Cockos Reaper) cause the External Input to drop out. It seems to happen when I rewind the sequencer, or arm/disarm tracks. I then have to re-enable the External Input in the Multimode screen to get it working again.
If I bind the External Input to a Bus instead, it never drops out.
I haven't tested this thoroughly, but my guess is that my DAW is sending some kind of a MIDI MMC/Sysex command and the Emu is responding by "un-enabling" External Inputs in Multimode.
Not a major problem, but a little annoying since having External Inputs enabled in Multimode gives you more flexible routing options than binded inputs.
Let me know if you're able to duplicate this "feature".